MIVAC researchers publishes data on covalently stabilized amyloid-β aggregates.
The data is presented in the scientific journal PNAS (Proceedings of the National Academy of Sciences of the United States of America). The uniquely stabilized aggregates (or oligomers) presented in the article are virtually indistinguishable from the soluble aggregates found in Alzheimer’s Disease patients’ brains, which are considered by many to be the main culprit in the disease. Unlike other preparations of oligomeric amyloid-β, the covalently stabilized oligomers invented by the MIVAC researchers are remarkably stable and homogeneous. Like wild-type oligomers they are also potent inducers of neuronal apoptosis. There are currently no therapeutics, biological or other, that specifically target these oligomers.
These stabilized preparations of oligomers are currently being used by MIVAC Development in the development of novel therapeutics specifically aimed at the toxic aggregates.
The findings presented in the article is a result from collaboration between MIVAC at the University of Gothenburg, the Swedish University of Agricultural Sciences, Uppsala University, and the University of Cambridge. Authors Anders Sandberg (PhD), Bertil Macao (PhD), and professor Torleif Härd (PhD) performed parts of the research while active at MIVAC. AS and TH are now part of the Operational Team of MIVAC Development AB.
The article was published online before print on August 16, 2010, at www.pnas.org. Click here to read it.